plerenone Reduces Mortality 0 Days After Randomization Following cute Myocardial Infarction in Patients With eft Ventricular Systolic Dysfunction and Heart Failure
نویسندگان
چکیده
ertram Pitt, MD, FACC,* Harvey White, DSC, FACC,† Jose Nicolau, MD, FACC,‡ elipe Martinez, MD,§ Mihai Gheorghiade, MD, FACC, Michael Aschermann, MD,¶ irk J. van Veldhuisen, MD, FACC,# Faiez Zannad, MD,** Henry Krum, MD,†† obin Mukherjee, PHD,‡‡ John Vincent, MD, PHD,‡‡ for the EPHESUS Investigators nn Arbor, Michigan; Auckland, New Zealand; São Paulo, Brazil; Cárdoba, Argentina; Chicago, Illinois; rague, Czech Republic; Groningen, the Netherlands; Nancy, France; Melbourne, Australia; and New York, New York
منابع مشابه
Eplerenone reduces mortality 30 days after randomization following acute myocardial infarction in patients with left ventricular systolic dysfunction and heart failure.
OBJECTIVES This study sought to assess the impact of the selective aldosterone blocker eplerenone on mortality 30 days after randomization in patients after acute myocardial infarction (AMI) with a left ventricular ejection fraction (LVEF) < or =40% and clinical signs of heart failure. BACKGROUND In the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPH...
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AIMS To test the hypothesis that an earlier post-acute myocardial infarction (AMI) eplerenone initiation in patients with left ventricular systolic dysfunction (LVSD) and heart failure (HF) is associated with better long-term outcomes. METHODS AND RESULTS The 6632 patients of the EPHESUS study were randomized from day 3 to 14 after the index AMI (median = 7 days), of these 3319 were assigned ...
متن کاملPreviously known and newly diagnosed atrial fibrillation: a major risk indicator after a myocardial infarction complicated by heart failure or left ventricular dysfunction.
AIMS To characterize the relationship between known and newly diagnosed atrial fibrillation (AF) and the risk of death and major cardiovascular (CV) events in patients with acute myocardial infarction (MI) complicated by heart failure (HF) and/or left ventricular systolic dysfunction (LVSD). METHODS The VALIANT trial enrolled 14,703 individuals with acute MI complicated by HF and/or LVSD. AF ...
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Background: There are some conflicting results with Conventional Coronary Artery Bypass Grafts (CCABG) with arrested heart in coronary high-risk patients. Moreover, performing off-pump CABG in these cases may be associated with serious complications. The objective of this study is to evaluate the efficacy of the on-pump beating CABG (OPBCABG) in coronary high-risk patients in comparison with th...
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تاریخ انتشار 2005